Norwegian clinical team finds what caused the suspected AstraZeneca sideffects. : worldnewsMarch 18, 2021
Professor on suspected vaccine side effects: – The cause has been found The experts who have examined the three hospitalized health workers believe that the AstraZeneca vaccine triggered a strong immune response. One of the health workers died.
A group at Rikshospitalet, led by Holme, has worked hard to find out why three health workers under the age of 50 were admitted with severe blood clots after taking the AstraZeneca vaccine.
The experts have worked on the basis of a hypothesis that the vaccines triggered an unexpected immune reaction in the sick health workers, who have triggered the system so that a combination of blood clots and low platelets has been obtained.
It is this theory that they now believe they have confirmed.
Our theory that this is a strong immune response that most likely comes after the vaccine, has been found. In collaboration with the section for advanced platelet immunology at UNN, we have now detected specific antibodies against platelets that can give such an image, which we know from other parts of the medicine, but then with drugs as the triggering cause, the superior explains.
You say most likely?
We have the cause. And there is no other thing than the vaccine that can explain that we have received that immune response, says Holme.
Why nothing more than the vaccine?
Because we have no other history in these patients that can give such a strong immune response. I’m pretty sure it’s these antibodies that’s the cause, and I see no other reason than that it’s the vaccine that triggers it.
Around 120,000 Norwegians have so far been vaccinated with AstraZeneca. Thus, very few cases of suspected serious side effects have been reported among the total number of vaccinated. Norway has temporarily paused vaccination, read more further down in the case.
Holme emphasizes that it is not antibodies in the blood in general that are the problem.
We are talking about very specific antibodies.
What has happened in the body from the time they took the vaccine until the disease happened?
We take the vaccine to get an immune response to what we are to be protected against. Then you get, among other things, the development of antibodies. Some antibodies can then react so that they can activate the platelets, as in these cases, and cause a blood clot. And because we have these antibodies on the surface, they are removed from the circulation, thus they get too low platelets, says Holme.
On Sunday, one of the three health workers who were admitted to Rikshospitalet died . They have all been treated for a very rare condition :
They came in with acute pain
They had blood clots in unusual places, such as the stomach and brain
In addition, they had bleeding and low platelet counts
Large parts of Europe, including Norway, have in the last week put the AstraZeneca vaccination on pause .
After Norway and Denmark reported the suspected serious side effects, other countries have reviewed their own data to look for similar cases.
Steinar Madsen at the Norwegian Medicines Agency says they have been informed that Rikshospitalet has meant that there is talk of a strong immune response – but he says he can not comment on details now.
The Adverse Reaction Committee of the European Medicines Agency (EMA), where Norway also sits, has a meeting on Thursday about the case and is expected to issue a statement.
This will to a large extent also be taken into account when assessing this on a European basis, that Norway has made such a solid effort to find out about this here, says Madsen.
Once the EMA has issued a statement, it is up to national authorities to decide the way forward for their respective countries.